Quick links

 


Lumi-cell Mechanism title

Lumi-Cell Mechanism

Lumi Cell Mechanism Description

Endocrine disrupting chemicals (EDCs) have been shown to affect normal hormone responses in both humans and wildlife. Concerns about these chemicals have increased worldwide as studies have suggested that these chemicals may be associated with global increases in testicular cancer, regional declines in sperm counts, altered sex ratios in wildlife populations, increases in the incidence of breast cancer and endometriosis, and accelerated puberty in females. In contrast to Dioxins and related Dioxin-Like Halogenated Aromatic Hydrocarbons that produce their effects by directly binding to and activating or inhibiting the Ah receptor, EDCs can affect a variety of hormone signaling pathways by a variety of direct and indirect mechanisms. However, although there are diverse action of EDCs, the majority of these mechanisms converge to affect a common endpoint, that of altering hormone receptor dependent gene expression. The specific receptor for estrogens and estrogenic chemicals (i.e. estrogen receptor (ER)) is present in the nucleus of responsive cells. Binding of estrogenic chemicals (including estrogenic EDCs) to the ER results in ER dimerization and conversion of the dimer into its DNA binding form. Binding of the estrogen-bound ER complex to its specific DNA binding site (called estrogen responsive elements (EREs) stimulates expression of the adjacent ER-responsive gene, which results in estrogenic responses. Alternatively, EDCs that block the function of the ER (antagonists) would lead to inhibition of ER-dependent gene expression and reductions in normal estrogenic responses.


Lumi Cell Mechanism Description



       home   |    about us    |    partners    |   publications     |     downloads     |     approvals     |     contact us

Xenobiotic Detection Systems  © 2007

Design by Walker Interactive Inc.